Sample interview questions: Can you explain any experience you have with computational biophysics or biological physics?
Sample answer:
Yes, I have experience in computational biophysics and biological physics.
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3D modeling of protein structures.
I have used computational methods to model the 3D structures of proteins. This involved using the amino acid sequence of the protein and then using a computer program to predict the structure of the protein. This information is then used to study the protein’s function and to design new drugs that target the protein. -
Protein-DNA interactions.
I have also studied the interactions between proteins and DNA. This involved using computer simulations to model the binding of proteins to DNA. This information is then used to study the regulation of gene expression and to design new drugs that target these interactions. -
Drug design.
Computational biophysics has also used to design new drugs. This involved using computer simulations to model the binding of drugs to their targets. This information is then used to design new drugs that are more effective and have fewer side effects. -
Biological physics.
Biological physics is the application of physical principles to understand biological systems. I have used biological physics to study a variety of biological systems, including: - The mechanics of muscle contraction.
- The electrical properties of neurons.
- The biophysics of photosynthesis.
Here are some specific examples of how I have used computational biophysics and biological physics in my work:
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Using computational methods to model the structure of the SARS-CoV-2 virus.
This work was done in collaboration with the University of California, San Francisco. The model was used to study the virus’s infectivity and to design new drugs that target the virus. -
Using computer simulations to study the binding of the drug remdesivir to the SARS-CoV-2 virus.
This work was done in collaboration with the University of California, Los Angeles. The simulations were used to design new… Read full answer