How do you approach the management of patients with endocrine complications of lung disease?

Sample interview questions: How do you approach the management of patients with endocrine complications of lung disease?

Sample answer:

Assessment

  • Detailed history: Inquire about symptoms of endocrine dysfunction, including fatigue, weight changes, polyuria, or menstrual irregularities.
  • Physical examination: Assess for signs of Cushing’s syndrome, thyroid enlargement, or gynecomastia.
  • Laboratory evaluation:
    • Thyroid function tests
    • Cortisol levels
    • Adrenal function tests
    • Bone mineral density scan
  • Imaging studies:
    • Chest X-ray or CT scan to exclude pulmonary masses or infiltrates
    • Ultrasound or MRI to visualize adrenal or thyroid glands

Management

  • Thyroid Dysfunction:
    • Hypothyroidism: Monitor TSH levels and treat with thyroid hormone replacement therapy.
    • Hyperthyroidism: Refer to an endocrinologist for evaluation and treatment.
  • Cushing’s Syndrome:
    • Identify the underlying cause (e.g., ectopic ACTH production, adrenal tumors)
    • Medical management with metyrapone or ketoconazole
    • Surgical resection of adrenal tumors
  • Adrenal Insufficiency:
    • Hydrocortisone replacement therapy
    • Educate patients about stress-dosing and salt intake
  • Osteoporosis:

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