Sample interview questions: Can you discuss any experience you have with genetic mapping software?
Sample answer:
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Experience with various genetic mapping software:
- EasyLinkage-Plus: Utilized EasyLinkage-Plus for linkage analysis in a large pedigree with a complex disease. Performed multipoint linkage analysis and identified several candidate regions linked to the disease.
- MapManager QTX: Employed MapManager QTX for quantitative trait locus (QTL) mapping in an experimental population. Conducted interval mapping and identified several QTLs associated with phenotypic traits.
- Tetrad Analysis Program: Used the Tetrad Analysis Program for genetic mapping in yeast. Constructed genetic maps and performed tetrad analysis to identify genetic interactions among genes.
- GenoMap: Applied GenoMap for linkage analysis in a genome-wide association study (GWAS). Conducted single-nucleotide polymorphism (SNP) genotyping and performed association analysis to identify genetic variants associated with a disease.
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Expertise in algorithms and statistical methods used in genetic mapping:
- Multipoint linkage analysis: Proficient in multipoint linkage analysis methods, including the Lander-Green algorithm and the Kong-Cox algorithm.
- QTL mapping: Familiar with various QTL mapping methods, such as interval mapping and composite interval mapping.
- Linkage disequilibrium mapping: Experienced in linkage disequilibrium mapping methods, including the HapMap project and the International HapMap Project.
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Experience with genetic mapping projects:
- Participated in a research… Read full answer