Sample interview questions: Can you discuss any experience with the development and optimization of synthetic routes for APIs?
Sample answer:
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Experience with Route Scouting and Selection:
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Conducted extensive literature reviews and patent searches to identify potential synthetic routes for APIs.
- Evaluated various reaction pathways based on factors such as cost, yield, selectivity, and environmental impact.
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Utilized computational tools and software to predict the feasibility and optimize the reaction conditions.
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Expertise in Reaction Optimization:
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Conducted systematic experiments to optimize reaction parameters such as temperature, pressure, solvent, and catalyst.
- Employed statistical techniques (e.g., Design of Experiments) to efficiently explore the reaction space and identify optimal conditions.
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Developed strategies to minimize side reactions and improve product purity.
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Experience with Scale-Up and Process Development:
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Successfully scaled up synthetic routes from lab scale to pilot and production scales.
- Collaborated with process engineers to design and implement scalable manufacturing processes.
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Monitored and controlled process parameters to ensure consistent product quality and yield.
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Expertise in Impurity Profiling and Control:
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Conducted comprehensive impurity profiling studies using analytical techniques (e.g., HPLC, GC-MS).
- Identified and characterized impurities, including genotoxic impurities and potential degradants.
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Developed strategies to control impur… Read full answer
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