Sample interview questions: Can you discuss any experience you have with high-throughput screening of small molecules for agricultural applications?
Sample answer:
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Experience with HTS Platforms:
- Proficient in operating various high-throughput screening (HTS) platforms, including robotic systems, microplate readers, and liquid-handling instruments.
- Expertise in developing and optimizing HTS assays for a range of agricultural applications, including pest control, disease management, and plant growth regulation.
- Strong understanding of HTS data analysis and interpretation, including statistical methods and software tools.
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Small Molecule Library Design and Management:
- Experience in designing and managing small molecule libraries for HTS campaigns.
- Knowledge of chemical diversity strategies, combinatorial chemistry techniques, and library synthesis methods.
- Familiarity with database management systems for organizing and tracking small molecule compounds.
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Hit Identification and Optimization:
- Demonstrated ability to identify and prioritize hits from HTS screens using various criteria, such as potency, selectivity, and toxicity.
- Expertise in lead optimization strategies, including structure-activity relationship (SAR) studies and analog synthesis.
- Experience in conducting secondary assays and in vitro/in vivo studies to validate hits and assess their biological activity.
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Collaboration and Communication… Read full answer