Sample interview questions: Can you discuss your experience with the characterization and control of polymorphic forms in pharmaceutical compounds?
Sample answer:
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Experience in the characterization of polymorphic forms:
- Utilized various analytical techniques, such as powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and Raman spectroscopy, to identify and differentiate polymorphic forms.
- Developed and optimized methods for polymorph screening and stability testing.
- Applied advanced microscopy techniques, including scanning electron microscopy (SEM) and atomic force microscopy (AFM), to visualize and characterize polymorphic transformations.
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Expertise in the control of polymorphic forms:
- Implemented crystallization strategies, including controlled cooling, seeding, and solvent selection, to manipulate and select desired polymorphic forms.
- Developed and evaluated amorphous solid dispersions, co-crystals, and other modified forms to improve solubility, bi… Read full answer
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