Sample interview questions: How do you approach studying the pharmacokinetics of a drug in patients with hepatic diseases?
Sample answer:
- Assess Liver Function:
- Evaluate the degree of hepatic impairment using diagnostic tests such as liver function tests (LFTs), liver biopsy, or imaging studies.
- Determine the Child-Pugh or MELD score to classify the severity of liver disease.
- Consider Hepatic Metabolism Changes:
- Investigate the drug’s metabolism pathways and identify if they involve hepatic enzymes or transporters.
- Determine if the drug undergoes biotransformation, conjugation, or excretion in the liver.
- Adjust Dosing Regimens:
- Reduce the initial dose or dosing frequency based on the extent of hepatic impairment.
- Monitor drug levels closely to ensure therapeutic efficacy and minimize adverse effects.
- Consider alternative routes of administration (e.g., rectal, transdermal) to bypass hepatic metabolism.
- Extend dosing intervals to allow for slower elimination.
- Evaluate Drug-Drug Interactions:
- Assess the potential for drug-drug interactions, especially with other drugs metabolized or excreted by the liver.
- Adjust dosing regimens or consider alternative medications to minimize the … Read full answer