Sample interview questions: How do you approach studying the molecular mechanisms of drug resistance in pathogens?
Sample answer:
Approaching the Study of Molecular Mechanisms of Drug Resistance in Pathogens
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Identify and Quantify Resistance: Utilize molecular techniques (e.g., sequencing, PCR) to detect and measure the presence and magnitude of drug resistance.
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Examine Genetic Determinants: Conduct genomic and transcriptomic analyses to determine the genetic basis of resistance, such as mutations in drug targets or overexpression of efflux pumps.
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Investigate Biochemical Mechanisms: Employ enzyme assays, protein binding studies, and structural analysis to understand the biochemical mechanisms by which pathogens evade drug action.
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Explore Evolutionary Dynamics: Study the evolutionary forces driving drug resistance, including the role of genetic recombination, horizontal gene tra… Read full answer