Sample interview questions: What software or tools do you use for genetic analysis?
Sample answer:
- Sequence Analysis Software:
- DNASTAR Lasergene: Comprehensive suite for DNA and protein sequence analysis, including assembly, alignment, and annotation.
- CLC Main Workbench: User-friendly platform for sequence assembly, alignment, variant calling, and transcriptome analysis.
- BioEdit: Free and open-source sequence editor with features for alignment, annotation, and analysis.
- Genome Browsers:
- UCSC Genome Browser: Interactive genome browser for visualizing and exploring genomic data, including genes, variants, and regulatory elements.
- Ensembl Genome Browser: Comprehensive genome browser with a focus on gene annotation and comparative genomics.
- Integrative Genomics Viewer (IGV): High-performance genome browser for visualizing and analyzing large-scale genomic data.
- Variant Calling Software:
- GATK (Genome Analysis Toolkit): Widely used toolkit for variant calling and analysis in high-throughput sequencing data.
- FreeBayes: Fast and accurate variant caller for large-scale sequencing data.
- SAMtools: Versatile tool for variant calling, pileup generation, and alignment file manipulation.
- Genetic Analysis Software:
- PLINK: Software package for whole-genome association studies, linkage analysis, and population genetics.
- LDLink: Tool for linkage disequilibrium analysis and haplotype block identification.
- Haploview: Software for haplotype analysis, visualization, and association testi… Read full answer