Sample interview questions: How do you assess the potential risks of exposure to chemical substances in pharmaceutical products?
Sample answer:
- In vitro studies: These studies use cultured cells or tissues to evaluate the potential toxicity of a substance. They can assess acute (short-term) or chronic (long-term) effects, such as cell death, DNA damage, or changes in gene expression.
- In vivo studies: These studies use live animals to evaluate the potential toxicity of a substance. They can assess the effects of different routes of exposure (e.g., oral, dermal, inhalation) and durations of exposure (e.g., acute, subchronic, chronic). In vivo studies can also provide information on the absorption, distribution, metabolism, and excretion of the substance, as well as its target organs and potential adverse effects.
- Toxicokinetic studies: These studies investigate the absorption, distribution, metabolism, and excretio… Read full answer