Sample interview questions: How do you approach studying the role of neuroinflammation in neurodevelopment?
Sample answer:
Comprehensive Approach to Studying Neuroinflammation in Neurodevelopment:
1. Advanced Imaging Techniques:
– Employ high-resolution microscopy (e.g., confocal, electron microscopy) to visualize inflammatory cells, their localization, and interactions with neurons and glial cells.
– Utilize advanced non-invasive imaging modalities (e.g., MRI, PET) to assess neuroinflammation in vivo and correlate it with neurodevelopmental outcomes.
2. Molecular Biology and Genetics:
– Conduct gene expression analysis (e.g., RNA-seq, qPCR) to identify key molecules involved in neuroinflammation and neurodevelopment.
– Use genetic animal models to investigate the specific role of inflammatory genes and pathways in neurodevelopmental disorders.
3. In Vitro and In Vivo Models:
– Establish primary neuronal and glial cultures to study neuroinflammation and its effects on neuronal function.
– Generate animal models of neuroinflammation using immune activators or inflammatory stimuli to mimic neurodevelopmental conditions.
4. Neurobehavioral and Cognitive Assessments:
– Perform behavioral and cognitive tests … Read full answer