Sample interview questions: Have you ever faced challenges in the development and optimization of dry powder inhaler formulations? How did you address them?
Sample answer:
Challenges Encountered:
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Particle size and morphology control: Achieving optimal particle size distribution and morphology is crucial for inhalation performance. I addressed this by employing advanced techniques such as spray drying, supercritical fluid extraction, and mechanical attrition to tailor particle properties.
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Drug stability: Dry powder inhaler formulations are susceptible to degradation over time. I implemented various strategies to enhance stability, including the use of protective excipients, encapsulation technologies, and optimization of storage conditions.
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Delivery efficiency: Ensuring high pulmonary deposition efficiency is paramount. I employed computational models and in vitro characterization techniques to optimize particle characteristics and device design for optimal drug delivery to the target site.
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Moisture sensitivity: Dry powder inhalers can be sensitive to moisture, affecting their performance and stability. I developed moisture-resistant formulations using desiccants, protective coatings, and vapor-impermeable packaging materials.
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Excipient interactions: Understanding and mitigating interactions between drug and excipients is essential. I utilized advanced analytical techn… Read full answer
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