Sample interview questions: Can you discuss any experience you have with studying the biochemistry of lipid signaling pathways?
Sample answer:
Biochemistry of Lipid Signaling Pathways
My research expertise encompasses the multifaceted biochemistry of lipid signaling pathways, particularly focusing on:
- Phospholipid metabolism: I have extensively studied the enzymes involved in the synthesis, catabolism, and remodeling of phospholipids, including phospholipase A2 (PLA2) and phosphatidylinositol 3-kinase (PI3K).
- Sphingolipid regulation: I have investigated the regulatory mechanisms of sphingolipid biosynthesis, including the role of ceramide synthases and sphingosine kinases. My findings have shed light on the involvement of sphingolipids in apoptosis and cell proliferation.
- Eicosanoid signaling: I have characterized the enzymes that generate eicosanoids, such as cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 epoxygenases. My work has elucidated the contributions of eicosanoids to inflammation, pain, and cardiovascular disease.
- Lipid-protein interactions: I have employed advanced techniques, such as lipidomics and mass spectrometry, to identify and characterize the lipid-protein interaction… Read full answer