Sample interview questions: How do you approach the process of designing experiments to investigate the effects of potential therapeutic interventions?
Sample answer:
Approaching the Design of Therapeutic Intervention Experiments
- Define the therapeutic target: Identify the specific disease, condition, or biological mechanism that the intervention aims to address.
- Establish a hypothesis: Formulate a testable hypothesis that predicts the expected effects of the intervention on the target.
- Select appropriate models: Determine the most suitable animal or cell culture models to mimic the target system and provide meaningful experimental data.
- Determine experimental conditions: Establish the dose, timing, and administration route of the therapeutic agent, as well as the frequency and duration of treatment and observations.
- Establish control groups: Include both positive (known therapeutic) and negative (untreated) control groups to ensure validity and interpretability of results.
- Choose relevant outcome measures: Select appropriate biomarkers, assays, and imaging techniques to quantify the effects of the intervention on relevant biological processes and endpoints.
- Use appropriate statistical methods: Determine statistical tests and power analyses to ensure the ability to detect meaningfu… Read full answer
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