Sample interview questions: How do you approach the process of designing experiments to investigate the effects of potential interventions on aging-related diseases?
Sample answer:
Approaching the Design of Experiments for Investigating Interventions on Aging-Related Diseases
As a Biomedical Scientist with expertise in aging research, I adhere to a rigorous and systematic approach to designing experiments aimed at evaluating the effects of potential interventions on aging-related diseases.
1. Defining the Research Question and Hypothesis:
– Clearly articulate the specific aspect of aging-related disease to be investigated and formulate a testable hypothesis.
2. Model Selection:
– Choose an appropriate animal model or cellular system that closely reflects the disease of interest, considering factors such as disease progression, genetic similarity, and response to interventions.
3. Intervention Selection and Dosing:
– Select the intervention based on its potential to modulate the aging process or disease progression. Determine the appropriate dosage and route of administration through thorough literature review and pilot studies.
4. Experimental Design:
– Design a robust experimental setup with multiple treatment groups, controls, and appropriate sample sizes to ensure statistical power. Consider using randomization, blinding, and crossover designs to minimize bias and enhance validity.
5. Measurement Endpoints:
– Identify relevant endpoints that accurately measure the effects of the intervention on disease progression, lifespan, and biomarkers of aging. Include both objective (e.g., survival an… Read full answer
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