Sample interview questions: How do you approach studying the pharmacokinetics of a drug in patients with neurological disorders?
Sample answer:
Approaching Pharmacokinetic Studies in Patients with Neurological Disorders:
- Consider disease-specific factors: Determine if the neurological disorder affects drug absorption, distribution, metabolism, or excretion. For instance, in neurodegenerative diseases, blood-brain barrier integrity may be compromised, impacting drug delivery.
- Use appropriate study designs: Choose pharmacokinetic study designs that account for the neurological symptoms and limitations of the patients. For example, non-invasive methods (e.g., blood sampling) may be more feasible than invasive techniques (e.g., biopsies).
- Determine optimal dosing regimens: Adjust dosing and administration strategies to ensure adequate drug exposure with minimal adverse effects. This may involve considering factors such as disease severity, cognitive impairment, and co-administered medications.
- Monitor drug concentrations: Regularly measure drug levels in blood, cerebrospinal fluid, o… Read full answer