Sample interview questions: Can you discuss any experience you have with microarray-based cytogenetic techniques?
Sample answer:
- Experience with array comparative genomic hybridization (aCGH):
- Conducted aCGH studies to identify chromosomal imbalances in patients with developmental disorders, cancer, and infertility.
- Analyzed aCGH data using specialized software to detect copy number variations (CNVs), including gains, losses, and amplifications.
- Interpreted CNVs in the context of patient’s clinical presentation and family history to identify disease-causing genetic alterations.
- Expertise in single-nucleotide polymorphism (SNP) arrays:
- Utilized SNP arrays to identify genetic variations associated with diseases such as cancer, cardiovascular disorders, and neurological conditions.
- Performed genome-wide association studies (GWAS) to identify common genetic variants that contribute to disease susceptibility.
- Analyzed SNP array data using statistical and bioinformatics tools to identify significant associations between genetic variants and disease outcomes.
- Familiarity with fluorescence in situ hybridization (FISH):
- Performed FISH analysis to detect chromosomal abnormalities, gene amplifications, and deletions in various clinical samples, including blood, bone marrow, and tissue biopsies.
- Used FISH probes to visualize specific DNA sequences or genes of interest within cells.
- Interpreted FISH results to identify genetic alterations associated with diseases such as cancer and genetic syndromes.
- Experience with metaphase and interphase cytogenetic techniques:
- Performed karyo… Read full answer