Sample interview questions: Can you discuss the concept of laser-induced thermal therapy and its impact on tissue ablation?
Sample answer:
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Laser-induced thermal therapy (LITT) is a minimally invasive surgical technique that utilizes laser energy to generate localized heat within tissue, leading to controlled ablation and destruction of targeted cells.
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LITT is commonly employed for the treatment of various medical conditions, including tumors, diseased tissues, and vascular malformations, due to its precision, minimal collateral damage, and preservation of surrounding healthy tissue.
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The mechanism of LITT involves the absorption of laser energy by tissue chromophores, such as water, hemoglobin, and melanin, resulting in rapid heating and subsequent cell death through thermal damage.
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The temperature elevation during LITT can induce various cellular responses, including protein denaturation, DNA fragmentation, and membrane disruption, leading to cell death through apoptosis, necrosis, or vaporization.
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LITT can be performed using different types of lasers, including near-infrared (NIR) lasers, radiofrequency (RF) lasers, and diode lasers, with the choice of laser depending on the specific application and tiss… Read full answer