Sample interview questions: Can you discuss any experience with the characterization and control of amorphous and crystalline forms in pharmaceutical compounds?
Sample answer:
Characterization and Control of Amorphous and Crystalline Forms in Pharmaceutical Compounds
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Understanding the Physicochemical Properties of Amorphous and Crystalline Forms:
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Amorphous forms lack long-range molecular order, resulting in lower melting points, higher solubility, and improved dissolution rates compared to crystalline forms.
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Crystalline forms exhibit well-defined lattice structures, leading to higher stability, lower solubility, and slower dissolution rates.
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Analytical Techniques for Form Characterization:
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X-ray Diffraction (XRD): Distinguishes crystalline from amorphous forms based on the presence or absence of sharp peaks.
- Differential Scanning Calorimetry (DSC): Detects phase transitions and determines the melting temperature and enthalpy of crystallization.
- Thermal Gravimetric Analysis (TGA): Measures weight changes associated with dehydration or decomposition, providing insights into the stability and volatility of different forms.
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Nuclear Magnetic Resonance (NMR) Spectroscopy: Detects differences in molecular mobility and local structure between amorphous and crystalline forms.
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Methods for Controlling and Manipulating Form:
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Crystallization: Read full answer
Source: https://hireabo.com/job/5_2_16/Pharmaceutical%20Chemist