Sample interview questions: How do you approach studying the pharmacokinetics of a drug in patients with renal conditions?
Sample answer:
Approaching Pharmacokinetic Studies in Patients with Renal Conditions
- Assess renal function: Determine glomerular filtration rate (GFR) and creatinine clearance to estimate the extent of renal impairment.
- Adjust dosing: Modify drug dosing based on GFR and the drug’s renal clearance.
- Monitor drug levels: Regularly measure drug concentrations in the blood to ensure therapeutic levels and avoid toxicity.
- Use alternative routes of administration: Consider using non-renal routes (e.g., intravenous, transdermal) for drugs highly dependent on renal clearance.
- Evaluate drug metabolism: Investigate changes in drug metabolism due to altered renal function, which … Read full answer