Sample interview questions: Can you explain your knowledge of the mechanisms of acute versus chronic toxicity?
Sample answer:
Acute Toxicity
- Refers to adverse effects that result from a single or short-term exposure to a toxic substance.
- Typically characterized by a rapid onset of symptoms, often within hours or days.
- Can be caused by a variety of factors, including the inherent toxicity of the substance, the dose, and the route of exposure.
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Examples of acute toxicity include:
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Accidental poisoning from ingestion of a toxic substance
- Inhalation of high levels of a toxic gas
- Skin contact with a corrosive chemical
Chronic Toxicity
- Refers to adverse effects that result from long-term exposure to a toxic substance.
- Typically characterized by a gradual onset of symptoms, often over months or years.
- Can be caused by a variety of factors, including the inherent toxicity of the substance, the dose, the duration of exposure, and the route of exposure.
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Examples of chronic toxicity include:
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Cancer from exposure to asbestos or benzene
- Liver damage from chronic alcohol abuse
- Neurological damage from chronic exposure to lead
Mechanisms of Toxicity
- The mechanisms of acute and chronic toxicity can vary depending on the specific toxic substance and the route of exposure.
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Some common mechanisms of toxicity include:
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