Can you explain your knowledge of the mechanisms of acute versus chronic toxicity?

Sample interview questions: Can you explain your knowledge of the mechanisms of acute versus chronic toxicity?

Sample answer:

Acute Toxicity

  • Refers to adverse effects that result from a single or short-term exposure to a toxic substance.
  • Typically characterized by a rapid onset of symptoms, often within hours or days.
  • Can be caused by a variety of factors, including the inherent toxicity of the substance, the dose, and the route of exposure.
  • Examples of acute toxicity include:

  • Accidental poisoning from ingestion of a toxic substance

  • Inhalation of high levels of a toxic gas
  • Skin contact with a corrosive chemical

Chronic Toxicity

  • Refers to adverse effects that result from long-term exposure to a toxic substance.
  • Typically characterized by a gradual onset of symptoms, often over months or years.
  • Can be caused by a variety of factors, including the inherent toxicity of the substance, the dose, the duration of exposure, and the route of exposure.
  • Examples of chronic toxicity include:

  • Cancer from exposure to asbestos or benzene

  • Liver damage from chronic alcohol abuse
  • Neurological damage from chronic exposure to lead

Mechanisms of Toxicity

  • The mechanisms of acute and chronic toxicity can vary depending on the specific toxic substance and the route of exposure.
  • Some common mechanisms of toxicity include:

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    Source: https://hireabo.com/job/5_1_38/Toxicologist

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