Sample interview questions: How do you evaluate and select appropriate reaction conditions for specific organic transformations?
Sample answer:
1. Understanding the Reaction Mechanism:
– Identify the reaction mechanism and determine the key factors influencing its outcome.
– Consider factors such as nucleophilicity, electrophilicity, steric effects, and temperature dependence.
2. Reactant and Product Properties:
– Analyze the physical and chemical properties of the reactants and products.
– Evaluate their solubility, stability, volatility, and reactivity under different conditions.
3. Reaction Temperature:
– Determine the optimal temperature range for the reaction.
– Consider the effect of temperature on reaction rate, selectivity, and side reactions.
4. Reaction Solvent:
– Choose a suitable solvent that can dissolve the reactants and products efficiently.
– Consider factors such as polarity, protic/aprotic nature, and ability to stabilize intermediates.
5. Catalyst or Reagent Selection:
– Identify suitable catalysts or reagents that can promote the desired transformation.
– Evaluate their activity, selectivity, and compatibility with the reaction conditions.
6. Reaction Time and Stoichiometry:
– Determine the appropriate… Read full answer