Sample interview questions: Can you describe your experience with conducting pharmacokinetic-pharmacodynamic modeling for drugs used in aquaculture?
Sample answer:
- Conducted pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation studies for several drugs used in aquaculture, including antibiotics, antifungals, and antiparasitics.
- Developed and validated PK-PD models using nonlinear mixed-effects modeling software (e.g., NONMEM, Monolix) using data from in vitro and in vivo studies.
- Characterized the PK-PD relationship of drugs, including dose-response relationship, time course of drug effect, and variability in drug response.
- Performed sensitivity analysis and uncertainty analysis to evaluate the robustness of the PK-PD model and identify critical parameters influencing drug efficacy and safety.
- Utilized PK-PD modeling to optimize dosing regimens, predict drug exposure, and assess the risk of resistance development.
- Collaborated with scientists from various disciplines, including pharmacologists, toxicologists, and veterinarians, to integrate PK-PD data and develop comprehensive models for drug evaluation.
- Presented findings at scientific conferences and authored publications in peer-reviewed journals. Read full answer