Sample interview questions: Describe your knowledge of drug discovery and development processes.
Sample answer:
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Target identification and validation: Identifying and confirming specific biological targets involved in disease processes. This involves employing molecular biology techniques, biochemical assays, and computational modeling.
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Lead generation and optimization: Generating and refining small molecule compounds that interact with the target and exhibit desired biological activity. This entails synthesis, screening, and structure-activity relationship (SAR) studies.
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Preclinical development: Evaluating candidate compounds in animal models to assess efficacy, safety, and pharmacokinetic properties. This includes toxicology, pharmacology, and efficacy studies.
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Clinical development: Conducting human clinical trials to evaluate safety, efficacy, and dosage in humans. This involves three phases of clinical trials: Phase I (safety), Phase II (efficacy and dosage), and Phase III (large-scale efficacy and safety).
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Regulatory approval: Submitting data from clinical trials and other studies to regulatory agencies (e.g., FDA, EMA) … Read full answer