Sample interview questions: Can you describe a challenging bioinformatics project you worked on and how you overcame the challenges?
Sample answer:
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Project: Developing a computational pipeline to identify novel targets for cancer therapy.
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Challenge: The project involved analyzing a large dataset of genomic and transcriptomic data to identify genes that are overexpressed in cancer cells. The challenge was to develop a computational pipeline that could efficiently process and analyze the data, and to identify genes that were specifically overexpressed in cancer cells and not in normal cells.
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Solution: I overcame the challenge by using a combination of machine learning and statistical methods to develop a computational pipeline that could efficiently process and analyze the data. I used a support vector machine (SVM) classifier to identify genes that were differentially expressed in cancer cells and normal cells, and then used a gene set enrichment analysis to identify genes that were specifically overexpressed in cancer cells.
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Outcome: The project resulted in the identification of several novel targets for cancer therapy. The computational pipeline that I developed was also published in a peer-reviewed journal, and has been used by other researchers to identify novel targets f… Read full answer
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