Sample interview questions: Can you discuss any experience you have with statistical design of experiments (DOE) in chemistry research?
Sample answer:
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Design of Experiments (DOE) Experience in Chemistry Research:
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Conducted a fractional factorial DOE to optimize the reaction conditions for a novel organic synthesis. The experiment involved varying four factors at two levels each, resulting in 16 experimental runs. The data were analyzed using ANOVA to identify the significant factors and their interactions. The optimized reaction conditions led to a significant improvement in the yield and selectivity of the desired product.
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Used a central composite design (CCD) to study the effect of three independent variables on the performance of a heterogeneous catalyst. The CCD consisted of 20 experimental runs, including replicates at the center point. The data were analyzed using response surface methodology to develop a mathematical model that predicted the catalyst performance as a function of the input variables. The model was used to optimize the catalyst composition and operating conditions for maximum activity and selectivity.
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Applied a Taguchi design to optimize the formulation of a polymer blend. The experiment involved varying five factors at three levels each, resulting in 27 experimental runs. The data were … Read full answer
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